Characteristics of intestinal flora levels in hypertensive patients with different cardiovascular risk level and their correlation with metabolic indicators
10.3969/j.issn.1008-0074.2024.06.18
- VernacularTitle:不同心血管危险分层高血压患者肠道菌群水平特征及与代谢指标的相关性
- Author:
Rui MENG
1
;
Xiang-nan LI
;
Hui-min LIU
;
Lin LI
;
Yang LIU
;
Yan-hong WANG
;
Zhong YI
Author Information
1. 航天中心医院老年医学一科,北京 100049
- Publication Type:Journal Article
- Keywords:
Hypertension;
intestinal flora;
Creatinine
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2024;33(6):739-743
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate intestinal flora levels in hypertensive patients with different cardiovascular risk level and their correlation with metabolic indicators.Methods:A total of 127 patients with essential hypertension admitted in Aerospace Central Hospital between February 2019 and May 2022 were retrospectively selected.Accord-ing to cardiovascular risk stratification,they were divided into low-medium risk group(n=37),high risk group(n=52)and extremely high risk group(n=38).Levels of blood lipids,serum creatinine(Scr)and intestinal flora were compared among three groups;association of intestinal flora levels with blood lipid,Scr levels were analyzed by Spearman method.Results:As cardiovascular risk level increased,levels of Bifidobacterium,Bacteroides the-taiotaomicron and Lactobacillus significantly reduced,and levels of Scr,Eubacterium rectale,Escherichia coli and Enterococcus significantly rose in the order of low-medium risk group,high risk group and extremely high risk group(P＜0.001 all).Spearman correlation analysis indicated that cardiovascular risk level was significant positively correlated with levels of Scr,Eubacterium rectale,Escherichia coli and Enterococcus(r=0.803～0.912,P＜0.001 all),and significant inversely correlated with levels of Bifidobacterium,Bacteroides thetaiotaomicron and Lactobacillus(r=-0.710～-0.834,P＜0.001 all)in hypertensive patients.Conclusion:Cardiovascular risk level is closely associated with intestinal flo-ra levels in hypertensive patients,suggesting that flora may regulate blood pressure to some extent.
