Effectiveness and safety of ginkgo biloba preparation combined with nicorandil in the treatment of an-gina pectoris of coronary heart disease:a meta-analysis
10.3969/j.issn.1008-0074.2024.06.14
- VernacularTitle:银杏叶制剂联合尼可地尔治疗冠心病心绞痛有效性与安全性的Meta分析
- Author:
Shu-yue LI
1
;
Xiang GAO
;
Wen-jing XU
;
Xiao-xuan ZHU
;
An-quan YAN
Author Information
1. 潍坊医学院临床医学院,山东潍坊 261053
- Publication Type:Journal Article
- Keywords:
Coronary disease;
Angina pectoris;
Ginkgo biloba extracts;
Nicorandil
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2024;33(6):720-724
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To systematically evaluate the effectiveness and safety of ginkgo biloba preparation combined with nicorandil in the treatment of angina pectoris of coronary heart disease.Methods:We searched CNKI,CBM,Wanfang,VIP,PubMed,the Cochrane Library and Embase for randomized controlled trials(RCTs)and cohort studies comparing the effectiveness and safety upon angina pectoris of coronary heart disease between ginkgo biloba preparation combined with nicorandil versus standard therapy or nicorandil monotherapy before October 2022.Revman 5.4.1 software was used to perform meta-analysis,while Stata 16.0 software was applied to conduct publication bias analysis.Results:A total of 10 studies were enrolled,including 1167 patients.Meta-analysis re-sults showed that compared with those in control group,patients in trial group had significant higher total effective rate(OR=3.87,95％CI 2.59～5.78,P＜0.001),and significant lower angina frequency(MD=-2.28,95％CI-2.66～-1.90,P＜0.001),angina duration(MD=-1.65,95％CI-2.12～-1.18,P＜0.001),nitroglycerin dosage(SMD=-2.89,95％CI-3.15～-2.62,P＜0.001)and incidence of adverse reactions(OR=0.40,95％CI0.24～0.66,P＜0.001).Conclusion:Ginkgo biloba preparation combined with nicorandil are more effective and safer than nicorandil monotherapy and conventional western medicine in the treatment of angina pectoris of cor-onary heart disease.
