A Randomized controlled study on the efficacy of HAIC sequential DEB-TACE in the treatment of colorec-tal cancer liver metastasis
10.3969/j.issn.1006-5725.2025.17.016
- VernacularTitle:肝动脉灌注化疗序贯载药微球经肝动脉化疗栓塞治疗结直肠癌肝转移的有效性随机对照研究
- Author:
Mengying ZHANG
1
;
Yaokai MA
;
Yifan DU
;
Wei ZHANG
;
Bo ZHOU
;
Xiyi YANG
Author Information
1. 上海市徐汇区中心医院介入科(上海 200030)
- Publication Type:Journal Article
- Keywords:
colorectal cancer;
liver metastasis;
hepatic artery infusion chemotherapy;
drug-eluting beads transcatheter arterial chemoembolization;
randomized controlled trial
- From:
The Journal of Practical Medicine
2025;41(17):2721-2727
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the efficacy of hepatic arterial infusion chemotherapy(HAIC)sequential drug-eluting beads transcatheter arterial chemoembolization(DEB-TACE)in the treatment of liver metastases from colorectal cancer.Methods 86 patients with colorectal cancer liver metastasis admitted to multiple centers from September 2022 to September 2023 were selected and divided into a control group(43 cases)and an experimental group(43 cases)according to the random number table method.The control group was treated with HAIC,and the experimental group was treated with HAIC sequential DEB-TACE.The clinical data and the changes of tumor markers and liver function indexes before and after treatment were compared between the two groups,and the short-term and long-term efficacy was evaluated,and the adverse reactions were recorded.Results After treatment,the levels of carcinoembryonic antigen,carbohydrate antigen 125,carbohydrate antigen 199,carbohydrate antigen 242,aspartate aminotransferase,alanine aminotransferase,alkaline phosphatase and γ-glutamyl transpeptidase in the two groups decreased(P<0.05),and those in the experimental group were lower than the control group(P<0.05).The proportion of repeated treatment in the experimental group was lower than that in the control group(P<0.05).The objective remission rate and disease control rate in the experimental group were 60.00%and 82.50%respectively,which were higher than 30.95%and 61.90%in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the control group and the experimental group(P>0.05).The results of Kaplan-Meier survival curve showed that the overall survival rate and progression-free survival rate of the experimental group were higher than those of the control group(P<0.05).Conclusions HAIC sequential DEB-TACE can effectively remove tumor cells and improve liver function in patients with colorectal can-cer liver metastasis,and it has good clinical efficacy and can prolong the survival time of patients.
