Predictive value of serum TRIB3 and STOX1 levels for prognosis in patients with coronary heart disease after PCI
10.3969/j.issn.1008-0074.2024.06.07
- VernacularTitle:血清TRIB3、STOX1水平对冠心病患者PCI术后预后的预测价值
- Author:
Lin ZHANG
1
;
Qing-song CHEN
;
Guang-hong FENG
;
Zhong-hua ZHU
;
Mao-hai ZHANG
Author Information
1. 大冶市人民医院检验科,湖北 黄石 435100
- Publication Type:Journal Article
- Keywords:
Coronary disease;
Angioplasty,Balloon,Coronary;
Tribbles pseudokinase 3;
Prognosis
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2024;33(6):683-687
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the predictive value of serum levels of tribbles pseudokinase 3(TRIB3)and storkhead box 1(STOX1)for prognosis in patients with coronary heart disease(CHD)after percutaneous coronary intervention(PCI).Methods:A total of 116 CHD patients undergoing PCI in Daye People's Hospital between May 2019 and August 2022 were enrolled as CHD group,another 95 healthy volunteers undergoing physical examination in our hospital simultaneously were selected as control group.According to presence of major adverse cardiovascular events(MACE)within 3 months after PCI,CHD group was divided into MACE group(n=21)and no MACE group(n=95).Enzyme-linked immunosorbent assay(ELISA)was used to measure serum TRIB3 and STOX1 levels;multivariate Logistic regression was used to analyze influencing factors of poor prognosis in CHD patients after PCI;receiver operating characteristic(ROC)curve was used to analyze predictive value of serum TRIB3 and STOX1 for poor prognosis in CHD patients after PCI.Results:Compared with participants in control group,those in CHD group had significant higher serum TRIB3 and STOX1 levels(P＜0.001 all).Compared with participants in no MACE group,those in MACE group had significant higher serum levels of TRIB3[(9.65±1.27)ng/ml vs.(12.04±1.64)ng/ml]and STOX1[(16.06±1.54)ng/ml vs.(18.21±1.78)ng/ml](P＜0.001 all).Multivariate Lo-gistic regression showed that serum TRIB3 and STOX1 levels were independent risk factors for MACE in CHD pa-tients after PCI(OR=3.859,2.159,P＜0.001 both).ROC analysis indicated that combined detection of serum TRIB3 and STOX1(area under the curve(AUC)=0.916)had higher predictive value for poor prognosis in CHD patients after PCI compared to those of single detection(AUC=0.837,0.776).Conclusion:Serum levels of TRIB3 and STOX1 significantly increase in CHD patients after PCI suffering from MACE,and the combination of both can better predict the prognosis of these patients.
