Prognostic and predictive values of tumor-stroma ratio in combination with fibrotic focus and stromal tumor-infiltrating lymphocytes for neoadjuvant therapy in triple-negative breast cancer
10.13315/j.cnki.cjcep.2024.11.009
- VernacularTitle:TSR联合纤维化中心与肿瘤间质淋巴细胞预测三阴型乳腺癌新辅助治疗的疗效与预后意义
- Author:
Tian XIA
1
;
Xin LONG
;
Rupei YE
;
Jing WANG
;
Jingbo CAI
;
Xue WEN
;
Xiuli XIAO
Author Information
1. 西南医科大学附属医院病理科,泸州 646000;西南医科大学附属医院重大疾病精准病理诊断泸州市重点实验室,泸州 646000
- Publication Type:Journal Article
- Keywords:
breast neoplasm;
triple-negative breast cancer;
TSR;
FF;
sTILs;
neoadjuvant therapy;
Miller-Payne grades;
pCR
- From:
Chinese Journal of Clinical and Experimental Pathology
2024;40(11):1168-1173,1180
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To investigate the correlation and prognostic value of tumor-stroma ratio(TSR)combined with fi-brotic focus(FF)and stromal tumor-infiltrating lymphocytes(sTILs)with pathological complete response(pCR)after neoad-juvant therapy in triple-negative breast cancer(TNBC).Meth-ods The clinical data of 170 cases of TNBC were collected.Af-ter double-blind reading of the sections by two senior patholo-gists,the pathological examination results of all cases were re-viewed,and the results of TSR,FF,sTILs and the expression of CD4 and CD8 were evaluated.Then the relationship between the above information and PCR and prognosis was analyzed.Results 170 cases of TNBC after neoadjuvant therapy,57 patients a-chieved pCR,while 113 patients did not achieve pCR.Statistical analysis revealed the following findings:TSR,FF,sTILs,CD4,CD8,Ki67,vascular invasion,and lymph node metastasis exhib-ited significant differences between the pCR and non-pCR groups.There were also significant differences in TSR,FF and sTILs between different Miller-Payne(MP)grades.TSR,sTILs,TSR combined with FF,sTILs and Ki67 were positively correlated with PCR.Meanwhile,TSR,sTILs,TSR combined with FF and sTILs were also positively correlated with MP grade,while FF,intravascular tumor thrombus and lymph node metasta-sis were negatively correlated with PCR.At the same time,TSR and sTILs were also positively correlated with MP grade,and FF was also negatively correlated with MP grade.The prognosis of patients was optimal with TSR＞1,G0 FF and sTILs＞50％.When TSR combined with FF and sTILs,the prognosis of PCR group was better than that of non-PCR group.Conclusion TSR,FF,and sTILs are anticipated to serve as predictive bio-markers for assessing the efficacy and prognosis of neoadjuvant therapy in TNBC patients.These findings offer novel insights into the treatment and research strategies for TNBC.
