Efficacy of ultrasound-guided ethanol injection combined with microwave ablation for treatment of very large volume benign thyroid nodules
10.3969/j.issn.1009-9905.2024.11.006
- VernacularTitle:超声引导无水乙醇注射联合微波消融治疗甲状腺超大体积良性结节的疗效
- Author:
Yan WANG
1
;
Hao SUN
1
;
Yi MAO
1
;
Chao ZHANG
1
;
Yu-kun LUO
1
;
Lin YAN
1
;
Ya-qiong ZHU
1
;
Ming-bo ZHANG
1
Author Information
1. 中国人民解放军总医院第一医学中心 超声诊断科,北京 100853
- Publication Type:Journal Article
- Keywords:
Thyroid nodule;
Benign;
Microwave ablation;
Ethanol
- From:
Chinese Journal of Current Advances in General Surgery
2024;27(11):867-872
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the efficacy of ultrasound-guided ethanol injection com-bined with microwave ablation (MWA) and MWA alone in the treatment of very large benign thyroid nodules. Methods:83 patients with benign thyroid nodules with volume>30 mL underwent ultrasound-guided thermal ablation were retrospectively analyzed from January 2020 to February 2023 in department of ultrasound,the first medical center of PLA general hospital. The patients were divided into two groups:ethanol injection combined with MWA (EA+MWA) group and MWA group. A comparison was made between the two groups in terms of ablation time,ablation energy,ablation energy per unit volume,nodule volume and reduction rate at 1,3,6 and 12 months post-surgery,symptom score,cosmetic score,thyroid function as well as intraoperative and postopera-tive complications. Results:The mean ablation time[(244.06±226.53)s vs (447.43±197.50)s,P<0.001],ablation energy[(8.15±9.60)kJ vs (15.24±7.61)kJ/mL]and unit volume ablation energy[(0.17±0.19)kJ/mL vs (0.34±0.16)kJ/mL]were significantly lower in EA+MWA group than those in MWA group(P<0.001). The VRR of EA+MWA group was significantly higher than that of MWA group at 6 months and 12 months after operation(P=0.002,P=0.011). Aesthetic and symptom scores were significantly lower in both groups 12 months after surgery(P<0.001). There was no significant change in thyroid function between the two groups during follow-up compared with be-fore treatment(P>0.05),and no serious complications were observed. Conclusion:ethanol in-jection before MWA can shorten the ablation time,reduce the microwave energy,and effectively promote the shrinkage of thyroid nodules.
