Effects of postoperative radiotherapy and other factors on the prognosis of metastatic sarcomatoid renal cell carcinoma based on SEER database
10.3969/j.issn.1009-8291.2025.08.010
- VernacularTitle:基于SEER数据库分析术后放疗等因素对转移性肉瘤样肾细胞癌预后的影响
- Author:
Shengping CAI
1
;
Pengcheng YANG
1
;
Tianyu LEI
1
;
Qinyong HU
1
Author Information
1. 武汉大学人民医院肿瘤中心,湖北武汉 430060
- Publication Type:Journal Article
- Keywords:
postoperative radiotherapy;
sarcomatoid renal cell carcinoma;
prognosis;
metastasis;
SEER database
- From:
Journal of Modern Urology
2025;30(8):689-694
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the effects of postoperative radiotherapy and other factors on the prognosis of metastatic sarcomatoid renal cell carcinoma(sRCC)so as to provide reference for the clinical decision-making.Methods Data of all sRCC patients during 2004-2018 were extracted from the American Surveillance,Epidemiology,and End Results(SEER)database,and 337 patients were ultimately enrolled.Patients were divided into the postoperative non-radiotheropy group(n=255)and postoperative radiotherapy group(n=82)based on different treatment modalities.Baseline data were compared between the two groups.The 1-year overall survival(OS)and cancer-specific survival(CSS)rates were calculated.Kaplan-Meier(K-M)survival curves were plotted.The prognostic factors were identified with univariate and multivariate Cox regression analyses.Results No significant differences were observed in baseline data between the two groups(P＞0.05).The 1-year OS(25.6％vs.30.1％)and CSS(26.2％vs.30.8％)in the postoperative radiotherapy group were lower than those in the postoperative no-radiotheropy group,but the differences were not statistically significant(P＞0.05).Multivariate Cox regression analysis showed that year of diagnosis,patients' age,tumor size,T stage,N stage and chemotherapy were independent prognostic factors of sRCC(P＜0.05).Patients diagnosed in 2015-2018 and treated with chemotherapy had a good prognosis,while patients＞61 years,with tumor size＞147 mm,tumor stage T3-T4,and stage N1 had a poor prognosis.Conclusion The year of diagnosis,patients'age,tumor size,tumor stage and chemotherapy were independent prognostic factors,and postoperative radiotherapy did not significantly improve the prognosis of metastatic sRCC patients.
