Neoadjuvant therapy strategies for advanced gastric cancer: Current innovations and future challenges
10.1016/j.cdtm.2020.03.004
- VernacularTitle:Neoadjuvant therapy strategies for advanced gastric cancer: Current innovations and future challenges
- Author:
Zhi ZHU
1
;
Ying-Bo GONG
1
;
Hui-Mian XU
1
Author Information
1. Department of Surgical Oncology, The First Hospital of China Medical University, Shenyang, Liaoning 110001, China
- Publication Type:Journal Article
- Keywords:
Gastric cancer;
Neoadjuvant therapy;
Chemotherapy;
Radiotherapy
- From:
Chronic Diseases and Translational Medicine
2020;06(3):147-157
- CountryChina
- Language:English
-
Abstract:
Gastric cancer, which has a high incidence and poor prognosis, remains a therapeutic challenge. Recently, neoadjuvant therapy has attracted increasing attention due to high recurrence rate and low survival rate after resection in most patients with advanced stage. Clinical trials show that neoadjuvant approaches confer a significant survival advantage for resectable locally advanced gastric cancer. The specific advantages of chemoradiotherapy compared with chemotherapy have not been clarified; optimal regimens and cycles, particularly in the preoperative setting, should be studied further; and trials aimed at determining the role of targeted and immunological therapies should be conducted.
