Study of correlation between Fli1 gene and prognosis and immunoinfiltration in patients with endometrial cancer
10.13431/j.cnki.immunol.j.20240083
- VernacularTitle:Fli1基因与子宫内膜癌患者预后及免疫浸润相关研究
- Author:
Wei LIAO
1
;
Yitong LIU
;
Toushen HONG
;
Lan LI
;
Lili SHEN
Author Information
1. 400030,重庆大学附属肿瘤医院病理科乳腺癌智能诊疗重庆市重点实验室
- Publication Type:Journal Article
- Keywords:
Fli1 gene;
Endometrial cancer;
Prognosis;
Immune infiltration
- From:
Immunological Journal
2024;40(7):593-600
- CountryChina
- Language:Chinese
-
Abstract:
Objective This study was to examine the association between the Fli1 gene and both prognosis and immune infiltration in patients with endometrial cancer.Methods Differential expression of the Fli1 gene was assessed utilizing the TIMER and GEPIA databases.The expression level of the FLI1 protein were evaluated through the Human Protein Atlas(HPA)database.The Kaplan-Meier Plotter database was employed to analyze the relationship between Fli1gene expression and patient prognosis in endometrial cancer.Additionally,the correlation between Fli1 gene expression and immune cell infiltration was investigated using the TIMER database.Results A significant underexpression of the Fli1gene in patients diagnosed with endometrial cancer(P<0.01).This was further corroborated by the Human Protein Atlas(HPA)database,which indicated a lower expression level of the FLI1 protein in tumor tissues compared to normal tissues.Furthermore,an analysis conducted using the Kaplan-Meier Plotter database demonstrated a correlation between low Fli1 gene expression and a poorer prognosis in endometrial cancer patients.TIMER database revealed a positive correlation between Fli1 expression and the infiltration of various immune cells,including B cells,CD4+T cells,and macrophages.The expression level of the Fli1 gene demonstrated a moderate to strong correlation with the marker genes of these immune cells(COR>0.4,P<0.05).Additionally,the expression of Fli1 gene was significantly positively correlated with multiple immune checkpoints.Conclusion The low expression of Fli1 is significantly associated with poor prognosis in patients with endometrial carcinoma,the higher infiltration of B cells,CD4+T cells,macrophages and other immune cells may play an important role.
