Alleviating ulcerative colitis with Baitouweng decoction through Nrf2/HO-1 pathway activation and HMGB1 downregulation
- VernacularTitle:白头翁汤通过HMGB1调控Nrf-2/HO-1信号通路缓解溃疡性结肠炎
- Author:
Wei-na ZHU
1
;
Chun-hua MA
1
;
Jie RUAN
1
;
Fu-qiong ZHOU
1
;
Ya-jie ZHANG
1
;
Hong-yan LONG
1
Author Information
- Publication Type:Journal Article
- Keywords: Baitouweng decoction; ulcerative colitis; Nrf2/HO-1 pathway; HMGB1; oxidative stress; DSS
- From: Chinese Pharmacological Bulletin 2025;41(1):186-192
- CountryChina
- Language:Chinese
- Abstract: Aim To explore the antioxidative effect of the Chinese medicine Baitouweng(BTW)on treating ulcerative colitis(UC).Methods Sixty male mice were randomly divided into six groups:control,dextran sulfate sodium(DSS)(3 g·105 L-1),BTW(20,10,and 5 g·kg-1),and 5-aminosalicylic acid(5-ASA)(800 mg·kg-1).UC model was constructed by 3％DSS for seven days,and the UC model was given by ga-vage once daily from the 5 th day of modeling for seven days.Results BTW effectively reduced the symptoms and histopathological scores of UC mice.Additionally,it downregulated the inflammatory factors,interleukin(IL)-6 and IL-1 β,the immunoglobulins vascular cell adhesion molecule 1 and intercellular adhesion mole-cule 1,and metalloprotease matrix metallopeptidase 9.Moreover,it downregulated high mobility group box 1 protein.Furthermore,it inhibited the nuclear factor er-ythroid 2-related factor 2(Nrf2)/heme oxygenase-1(HO-1)pathway.Conclusions BTW improves the general condition,inflammatory indexes and oxidative stress level,and its mechanism may be related to inhib-iting the level of HMGB1 to regulate the Nrf-2/HO-1 signaling pathway and rescue intestinal barrier-related protein expression.
