Correlation research between autophagy and pyroptosis in cerebral ischemic stroke
10.3969/j.issn.1000-484X.2025.09.039
- VernacularTitle:细胞自噬和细胞焦亡在缺血性脑卒中中的相关性研究
- Author:
Luyao LIU
1
;
Yi ZHANG
1
Author Information
1. 河北中医药大学,河北省心脑血管病中医药防治研究重点实验室,石家庄 050091
- Publication Type:Journal Article
- Keywords:
Cerebral ischemic stroke;
Autophagy;
Pyroptosis;
Occurrence mechanism
- From:
Chinese Journal of Immunology
2025;41(9):2296-2301
- CountryChina
- Language:Chinese
-
Abstract:
Cerebral ischemic stroke(CIS)is a common and frequently-occurring disease threatening human health.The mech-anism of CIS is very complex,involving energy metabolism disorder,oxidative stress,inflammatory,excitatory amino acids toxicity,and other aspects.Due to its complex pathogenesis,the treatment is rather difficult.Autophagy and pyroptosis are essential mecha-nisms of CIS.Proper autophagy can reduce neuronal damage and inhibit pyroptosis.Excessive autophagy can aggravate neuronal dam-age by promoting pyroptosis.How to balance autophagy and pyroptosis to reduce CIS nerve injury has become the research focus of the prevention and treatment of ischemic cerebrovascular disease.Studies have found that the interaction between autophagy and pyropto-sis can regulate the development process of CIS in the aspect of oxidative stress,endoplasmic reticulum stress,and inflammatory re-sponse.The related studies on the mechanism of autophagy and pyroptosis induced in CIS,and how the two interact with each other and affect the process of CIS are reviewed in this paper,to provide a reference for future research on new targets for the prevention and treatment of CIS.
