Mechanism and research progress of TLR/MyD88/NF-κB pathway in anti-infection immunity
10.3969/j.issn.1000-484X.2025.09.038
- VernacularTitle:TLR/MyD88/NF-κB信号通路在抗感染免疫中的作用及机制研究进展
- Author:
Zhenfang YAN
1
;
Jingying XIE
;
Zhenyang HOU
;
Yaxin ZHANG
;
Ruofei FENG
Author Information
1. 西北民族大学生物医学研究中心生物工程与技术国家民委重点实验室,兰州 730030;西北民族大学生命科学与工程学院,兰州 730030
- Publication Type:Journal Article
- Keywords:
TLRs/MyD88/NF-κB signaling pathway;
Viruses;
Immune mechanisms
- From:
Chinese Journal of Immunology
2025;41(9):2288-2295
- CountryChina
- Language:Chinese
-
Abstract:
Innate immune system serves as the primary defense mechanism against pathogen infections,recognition of structural components of pathogens is referred to as pathogen-associated molecular patterns(PAMPs).Toll-like receptors(TLRs)are a family of transmembrane receptors that can identify PAMPs,which interact with myeloid differentiation factor 88(MyD88)and activate NF-κB dimerization,leading to the release of downstream inflammatory factors and ultimately triggering the adaptive immune system.Conse-quently,TLRs are regarded as adapters that regulate the transition from innate immunity to adaptive immunity.TLR/MyD88/NF-κB signaling pathway plays a crucial role in inflammatory diseases,infectious diseases and tumor immunity.This review article aims to explore the regulatory function of TLR/MyD88/NF-κB signaling pathway in host responses to viral,bacterial,and other microbial in-fections,providing novel insights into the immune response during the process of infection control.
