Research progress of CCR3 and its ligands in pathogenesis of Alzheimer's disease
10.3969/j.issn.1000-484X.2025.09.037
- VernacularTitle:CCR3及其配体在阿尔茨海默病发病机制中的作用研究进展
- Author:
Ying YANG
1
;
Ying YU
1
;
Xiaorui CHENG
1
;
Hui SHEN
1
Author Information
1. 山东中医药大学中医药创新研究院,济南 250355
- Publication Type:Journal Article
- Keywords:
Alzheimer's disease;
Chemokine;
Chemokine receptor CC;
Chemokine receptor 3
- From:
Chinese Journal of Immunology
2025;41(9):2278-2287
- CountryChina
- Language:Chinese
-
Abstract:
Chronic neuroinflammation is one of the pathogeneses of Alzheimer's disease(AD),and chemokines and their re-ceptors play a key role in AD pathology.Studies have shown that the expression of CCR3 is increased in AD patients and animal models,and the absence or antagonism of CCR3 can effectively improve the pathological changes of AD animal models and improve the impairment of learning and memory function,which is a potential target for AD treatment.In this review,the research progress of the role of CCR3 and its ligands in the pathogenesis of AD is reviewed,which will provide references for the in-depth disclosure of the pathogenesis of AD and the development of new drugs.
