Cordycepin attenuates gentamicin-induced kidney injury by inhibiting oxidative stress and ferroptosis
- VernacularTitle:虫草素通过抑制氧化应激与铁死亡减轻庆大霉素诱导的肾损伤
- Author:
Lin YUE
1
;
Cao-mei XU
;
Min-yan QIAN
;
Wen-ting ZHANG
;
Xiao ZHENG
;
Lu-jun CHEN
;
Jing-ting JIANG
;
Nan HU
Author Information
- Publication Type:Journal Article
- Keywords: gentamicin; kidney injury; cordycepin; oxidative stress; ferroptosis; GPX4
- From: Chinese Pharmacological Bulletin 2025;41(1):65-70
- CountryChina
- Language:Chinese
- Abstract: Aim To investigate the effect of cordycepin(COR)on gentamicin(GEN)-induced nephrotoxicity and the molecular mechanism of inhibiting oxidative stress and ferroptosis induced by GEN.Methods The oral SD rats were divided into a control group,GEN group,and GEN+COR group.Following the success-ful setting up of the animal model,the serum creatinine(CR)and urea nitrogen(BUN)levels of rats were measured,and renal tissue injury was assessed using HE staining.In addition,the contents of malondialde-hyde and glutathione in kidney tissues of SD rats in each group were detected,and the expressions of fer-roptosis markers GPX4 and SLC7A11 were analyzed by Western blot.Results Compared with the control group,CR and BUN in GEN-stimulated group signifi-cantly increased(P＜0.01),and the level of CR and BUN was effectively reduced after 50 mg·kg-1 COR oral administration.HE results also showed that COR could alleviate the kidney tissue damage caused by GEN.COR could reverse the increase of malondialde-hyde level and the decrease of glutathione level caused by GEN in rat kidney tissue,and COR could restore the decrease of GPX4 and SLC7A11 protein levels induced by GEN.Conclusion COR can reduce GEN-induced kidney injury by inhibiting oxidative stress and ferrop-tosis.
