Association between residual cholesterol and metabolic associated fatty liver disease risk at different tri-glyceride levels
10.3969/j.issn.1006-5725.2025.17.010
- VernacularTitle:不同甘油三酯水平下残余胆固醇与代谢相关脂肪性肝病风险的关系
- Author:
Lili SU
1
;
Nuo LI
;
Wei FANG
;
Menghua CHEN
;
Sina QIN
;
Yegui YANG
Author Information
1. 桂林医科大学第一附属医院超声医学科(广西 桂林 541000)
- Publication Type:Journal Article
- Keywords:
metabolic-associated fatty liver disease;
remnant cholesterol;
triglyceride;
interaction effect
- From:
The Journal of Practical Medicine
2025;41(17):2676-2682
- CountryChina
- Language:Chinese
-
Abstract:
Objective This study aims to investigate the association between remnant cholesterol(RC)and the risk of metabolic-associated fatty liver disease(MAFLD)under the optimal triglyceride(TG)levels recom-mended by different guidelines.Methods The data were derived from the annual physical examinations of elderly people aged 65 and above in a community in 2023.Regression analysis was used to evaluate the association between RC and MAFLD risk.According to the TG normal level(<1.7 mmol/L)recommended by the Chinese Lipid Management Consensus and the TG ideal target(<1.2 mmol/L)proposed by the European Atherosclerosis Society,the individuals were divided into subgroups with different TG levels to explore the association between RC and MAFLD risk in each subgroup.Results A total of 2,800 elderly individuals aged 65 and above were included in this study.The proportion of the individuals meeting the diagnostic criteria for MAFLD was 20.85%,and RC was identified as an independent risk factor for MAFLD(P<0.001).In the elderly individuals with TG<1.7 mmol/L,RC level was not significantly associated with MAFLD risk(P=0.888).In contrast,in the elderly individuals with TG≥1.7 mmol/L,RC level was significantly and positively correlated with MAFLD risk(P<0.001).Interaction tests revealed no significant interaction between the stratification factor and the effect size of RC(P=0.115).In the elderly individuals with TG<1.2 mmol/L,RC level was not associated with MAFLD risk(P=0.505),while in the elderly individuals with TG≥1.2 mmol/L,RC level was significantly associated with MAFLD risk(P<0.001).Interaction tests showed a significant interaction between the stratification factor and the effect size of RC(P=0.011).Conclusion RC is an independent risk factor for MAFLD in older individuals.To reduce the risk of MAFLD related to RC in the elderly,a triglyceride level of<1.2 mmol/L can serve as a reference for identifying early-stage risk.
