Global Research Trends and Prospects of Epigenetic Modification in Ulcerative Colitis:Bibliometric and Visual Analysis 2003-2023
- VernacularTitle:表观遗传修饰在溃疡性结肠炎中的全球研究趋势及前景:2003-2023年文献计量学及可视化分析
- Author:
Chuxin WU
1
;
Siya LI
;
Zhao LAN
;
Huan ZHENG
;
Haomeng WU
;
Shaogang HUANG
Author Information
- Publication Type:Journal Article
- Keywords: Epigenetic; Ulcerative colitis; Bibliometrics; DNA methylation; MicroRNA
- From: World Science and Technology-Modernization of Traditional Chinese Medicine 2025;27(8):2161-2175
- CountryChina
- Language:Chinese
- Abstract: Objective Epigenetics,which changes the expression of DNA or protein by chemical modification,affects the regulation of genes and plays an important role in the interaction between genetic and environmental factors in diseases.This review focuses on the development trend and research hotspots of epigenetic modification in ulcerative colitis from 2003 to 2023.Methods Literature related to epigenetic modification in UC was obtained from the Web of Science Core Collection database,and bibliometric analyses and visualization were performed using VOSviewer,CiteSpace and R software.Results 1359 papers published from 2003-2023 were retrieved for inclusion in the analysis.The United States dominated the field of epigenetic modification,with the University of Chicago being the most published and cited institution,and Wu Feng of the Meyerhoff Center for Inflammatory Bowel Disease being the most cited author.The journals Inflammatory Bowel Diseases and Gastroenterology have high influence,screening for high-frequency keywords related to UC epigenetic modifications,including microRNA,inflammation,biomarker,azathioprine,DNA methylation,long noncoding RNA,circular RNA,received wide attention.Conclusion Epigenetics continues to evolve in the field of UC,providing important avenues in elucidating the pathogenesis of UC,in elucidating the interactions between genetics and the environment,and in giving new ideas for simplifying diagnosis,improving inflammation,and developing new drugs.
