Research progress on mechanism of opioid-induced pruritus
- VernacularTitle:阿片类药物诱导瘙痒的机制研究进展
- Author:
Fang MA
1
;
Pei-lan ZHOU
;
Rui-bin SU
Author Information
- Publication Type:Journal Article
- Keywords: opioid-induced pruritus; pruritus and analgesia; pruritus mechanism; opioid receptor; gastrin-releasing peptide receptor; pruritus treatment
- From: Chinese Pharmacological Bulletin 2025;41(1):29-34
- CountryChina
- Language:Chinese
- Abstract: Pruritus is one of the serious side effects in patients receiving opioid analgesia in clinic.A lot of studies have eluci-dated the analgesic mechanisms of opioids,but the mechanism of opioid-induced pruritus is still unclear,and the relationship between pruritus and analgesia is ambiguous.In the recent stud-ies,after activation of μ,κ and δ opioid receptors,opioids transmit itch information by interacting with the gastrin-releasing peptide receptor(GRPR)directly or indirectly.Neuropeptides such as neuromedin B(NMB),neuropeptide Y(NPY),B-type natriuretic peptide(BNP)and other receptors transient receptor potential vanilloids 1 receptor(TRPV1R),N-methyl-D-aspar-tate receptor(NMDAR)and 5-hydroxytryptamine(5-HT)re-ceptor also play important roles in morphine-induced itching.In addition,the prevention and treatment of opioid-induced pruritus are still one of the difficulties and hot spots of perioperative mor-phine analgesia.Therefore,it is important to clarify the specific occurrence mechanism of pruritus to find new research ideas for the prevention and treatment of opioid-induced pruritus.
