Research progress in roles of ginsenosides in regulating ligand-gated ion channels
10.3867/j.issn.1000-3002.2024.12.005
- VernacularTitle:人参皂苷调节配体门控离子通道研究进展
- Author:
Jiajun ZHONG
1
;
Yan LIU
;
Xingyang LIU
;
Ke WANG
;
Junrong ZHU
;
Yihua WEI
;
Jingyuan ZHENG
;
Guoqing ZHENG
;
Lei WEN
Author Information
1. 浙江中医药大学附属第一医院,浙江杭州 310006;厦门大学医学院,福建厦门 361102
- Publication Type:Journal Article
- Keywords:
ginsenosides;
ligand-gated ion channels;
ionotropic receptors
- From:
Chinese Journal of Pharmacology and Toxicology
2024;38(12):932-944
- CountryChina
- Language:Chinese
-
Abstract:
Ligand-gated ion channels transduce chemical signals into ionic currents while being bonded with specific ligands,thereby facilitating signal transduction and intercellular communication.These channels have become critical therapeutic targets for a variety of diseases.Ginsenosides,triter-penoid saponins primarily derived from herbs of the Panax genus,are known for their broad range of biological activities.Ginsenosides and their metabolites can regulate the functions of various ligand-gated ion channels,including nicotinic acetylcholine receptors,5-hydroxytryptamine type-3 receptors,γ-aminobu-tyric acid type-A receptors,glycine receptors,ionotropic glutamate receptors,ATP-gated P2X chan-nels,and transient receptor potential channels.They play important roles in anti-inflammation,analge-sics,immune regulation,anti-epilepsy,cognitive enhancement and neuroprotection.Further investiga-tion into the mechanisms by which ginsenosides regulate these channels will provide important evidence for their clinical applications and the development of new drugs.
