Application effects of skin care based on NCI grading on breast cancer patients with chemotherapy-induced hand-foot syndrome
10.3760/cma.j.cn115682-20250111-00180
- VernacularTitle:基于NCI分级的皮肤护理在乳腺癌化疗相关性手足综合征患者中的应用效果研究
- Author:
Qingqing ZHANG
1
;
Jinping QIAN
Author Information
1. 南通市肿瘤医院（南院）消化内科，南通 226001
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Hand-foot syndrome;
NCI grading;
Skin care
- From:
Chinese Journal of Modern Nursing
2025;31(33):4593-4597
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of skin care based on the National Cancer Institute (NCI) grading on breast cancer patients with chemotherapy-related hand-foot syndrome (HFS) .Methods:A convenience sampling method was used to select 72 female breast cancer patients with chemotherapy-induced HFS treated at Nantong Tumor Hospital from January 2019 to December 2021. Patients were randomly divided into an observation group ( n=36) and a control group ( n=36) using a random number generator. The control group received routine nursing intervention, while the observation group received skin care intervention based on NCI grading. The Numerical Rating Scale (NRS) , European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core-30 (EORTC QLQ-C30) , Morisky Medication Adherence Scale-8 (MMAS-8) , and Healthy Eating Index (HEI) were used for evaluation. Comparisons were made between the two groups before and after intervention in terms of NCI grading, main symptoms of HFS (numbness, skin erythema) grading, NRS score, and EORTC QLQ-C30 score, and the time to first HFS relief, as well as adherence to medication and diet, were assessed. Results:After nursing intervention, the distribution of NCI grades differed between the two groups, and the difference was statistically significant ( P<0.05) . The time to first relief of HFS in the observation group was earlier than in the control group, and the difference was statistically significant ( P<0.05) . The distribution of skin erythema grades between the two groups also differed, and the difference was statistically significant ( P<0.05) . The observation group had lower NRS scores, while MMAS-8, HEI, and EORTC QLQ-C30 scores were higher than those of the control group, and the differences were all statistically significant ( P<0.05) . Conclusions:Skin care based on NCI grading can improve symptoms of chemotherapy-related HFS in breast cancer patients, shorten the time to HFS relief, enhance quality of life, and improve treatment adherence. It is worthy of clinical application.
