Relationship between spleen volume and non-alcoholic fatty liver disease by three-dimensional computed tomography reconstruction
- VernacularTitle:基于CT三维重建技术探讨脾脏体积与非酒精性脂肪性肝病的关系
- Author:
Xiao LIANG
1
;
Caixia DONG
;
Guodong LI
;
Qi SHANG
;
Bowen QIN
;
Dan WAN
;
Qian WANG
;
Lu LI
;
Xin CHEN
;
Zongfang LI
Author Information
- Publication Type:Journal Article
- Keywords: Spleen Volume; Non-alcoholic Fatty Liver Disease; Imaging,Three-Dimensional; Mendelian Randomization Analysis
- From: Journal of Clinical Hepatology 2025;41(8):1548-1555
- CountryChina
- Language:Chinese
- Abstract: Objective To investigate the association of spleen volume with the risk of non-alcoholic fatty liver disease(NAFLD)as well as their causal relationship.Methods We included 90 NAFLD cases and 47 healthy controls who had received contrast-enhanced computed tomography(CT)scan of the abdomen at the Second Affiliated Hospital of Xi'an Jiaotong University from November 2022 to November 2023.We conducted three-dimensional reconstruction of the spleen through a deep learning network model using a two-stage coarse-to-fine segmentation approach.We compared the two groups using the two-sample t test or Mann-Whitney U test for continuous data and using the chi-square test for categorical data;evaluated the correlation between spleen volume and liver function indicators through Pearson correlation or Spearman rank correlation analyses;determined the factors influencing the development of NAFLD through multivariable Logistic regression analysis;and further assessed the casual relationship between spleen volume and NAFLD using the inverse variance-weighted two-sample Mendelian randomization(IVW-MR)method.Results Spleen volume was significantly larger in NAFLD cases than in controls(272.93±104.16 vs 204.37±81.20 cm3,P<0.001).The Spearman rank correlation analysis showed that spleen volume was positively correlated with the hepatic steatosis index(rs=0.422,P<0.001)and gamma-glutamyl transferase levels(rs=0.211,P=0.047)in patients with NAFLD.The multivariable Logistic regression analysis indicated that spleen volume was an independent risk factor for the development of NAFLD(odds ratio[OR]=1.01,95%confidence interval[CI]:1.00-1.02,P=0.049).The IVW-MR analysis detected a causal relationship between spleen volume and NAFLD(OR=1.16,95%CI:1.05-1.28,P=0.005).Conclusion Increased spleen volume may be a risk factor for the development and progression of NAFLD.Further studies are still needed to investigate the specific mechanism.
