Efficacy Analysis of Different Doses Remimazolam During Induction of General Anesthesia in Elderly Patients with Coronary Heart Disease Undergoing Non-cardiac Surgery
10.11969/j.issn.1673-548X.2025.08.021
- VernacularTitle:不同剂量瑞马唑仑对老年冠心病患者非心脏手术全身麻醉诱导的效果分析
- Author:
Biao ZHOU
1
;
Peng CUI
1
;
Jie HU
1
Author Information
1. 471003 郑州大学附属洛阳中心医院麻醉科
- Publication Type:Journal Article
- Keywords:
Remimazolam;
Elderly patients;
Coronary heart disease;
Induction of anesthesia
- From:
Journal of Medical Research
2025;54(8):129-133,67
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of different doses remimazolam during induction of anesthesia in elderly patients with coronary heart disease undergoing non-cardiac surgery.Methods A total of 120 elderly patients with non-cardiac surgery for coronary heart disease and received general anesthesia under tracheal intubation at Luoyang Central Hospital Affiliated to Zhengzhou University from October 2023 to October 2024,aged 60-85 years.The patients were divided into 3groups by random number table:group R1,group R2 and group R3,with 40 cases in each group,with anesthesia was induced with intravenous injection of remimazolam of 0.2,0.25,0.3mg/kg,respectively.Before induction(T1),modified observers assessment of alertness/sedation(MOAA/S)score reached to 0 points(T2),15seconds after intubation(T3),mean arterial pressure(MAP),heart rate(HR),cardiac output(CO),stroke volume variation(SVV),systemic vascular resistance(SVR),and regional cerebral oxygen saturation(rScO2)were compared among the three groups,as well as the time to loss of consciousness,use of vasoactive drugs,and the incidence of hiccups and hypoxemia were recorded.Results Compared with the T1,MAP and SVR decreased significantly in all groups at T2,with group R2 and R3 showing lower values than group R1(P＜0.05);at T3,the MAP and HR in group R,was higher than group R2 and group R3 compared with T1,the MAP and HR in group R1 were significantly increased at T3(P＜0.05).There was no significant difference in CO,SVV and rScO2 among three groups at different time(P＞0.05).The time of loss of consciousness reduced with the increase of the dose of remimazolam.The application pro-portion of esmololhydrochloride in group R1 and group R2 was more than group R3 during induction of general anesthesia(P＜0.05).There was no significant difference in incidence of adverse events among three groups(P＞0.05).Conclusion Remimazolam can be used safely and effectively for the induction of general anesthesia in elderly patients with coronary heart disease undergoing non-cardiac surger-y,and doses of 0.3mg/kg is more effective for anesthesia induction.
