Relationship Between TyG Index and ICU Mortality of Non-diabetic Sepsis
10.11969/j.issn.1673-548X.2025.08.017
- VernacularTitle:TyG指数与非糖尿病脓毒症ICU病死率的关系
- Author:
Yujing JIANG
1
;
Jiaqi WANG
1
;
Li MA
1
Author Information
1. 730030 兰州大学第二医院重症医学科
- Publication Type:Journal Article
- Keywords:
Insulin resistance;
Sepsis;
ICU mortality;
Triglyceride-glucose index
- From:
Journal of Medical Research
2025;54(8):101-107
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the relationship between triglyceride-glucose index(TyG)and intensive care unit(ICU)mor-tality in patients with non-diabetic sepsis.Methods The retrospective cohort study analyzed the data from sepsis patients admitted to the Second Hospital & Clinical Medical School,Lanzhou University between January 2018 and December 2023.The patients were divided into three groups based on the terartiles of the TyG index:group T1,group T2 and group T3,with ICU mortality as the primary endpoint.Multivariate COX regression analysis and restricted cubic spline(RCS)modeling were performed to investigate the potential non-linear relationship between the TyG index and ICU mortality of patients with sepsis,and subgroup analysis were conducted to further explore these relationships.Results This study included 578sepsis patients,with an ICU mortality of 16.96％.The Kaplan-Meier survival curve analysis indicated that the ICU mortality in the group T3 was significantly higher than that in the group T1.The RCS analysis re-vealed a linear relationship between the TyG index and ICU mortality,for every 1-unit increase in the TyG index,the risk of ICU mortal-ity increased by approximately 54％.Subgroup analysis demonstrated consistent effect directions across different subgroups,with no sub-group-specific effects,indicating the robustness of the results.Conclusion TyG index may serve as a potential biomarker for predicting ICU mortality in non-diabetic sepsis patients.
