Immunologic Features and Significance of Extramedullary Multiple Myeloma
10.11969/j.issn.1673-548X.2025.08.011
- VernacularTitle:髓外多发性骨髓瘤的免疫学特征及其意义
- Author:
Xiaosha LI
1
;
Xiaohuan PENG
1
;
Liansheng ZHANG
1
Author Information
1. 730000 兰州大学第二医院血液内科
- Publication Type:Journal Article
- Keywords:
Multiple myeloma;
Extramedullary lesions;
Immunological;
Clinical features
- From:
Journal of Medical Research
2025;54(8):63-67
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study whether there are differences in immunological and hematological indexes in patients with extramed-ullary multiple myeloma(EMM).Methods The medical records of 150 newly diagnosed multiple myeloma(MM)patients admitted to Department of Hematology,the Second Hospital of Lanzhou University from January 2019 to January 2024 were retrospectively analyzed,to compare and analyze the differences in immunological and some hematological indexes between the EMM group(n=60)and the non-EMM group(n=90),and the two subgroups of the different risk stratification DS stages and Mayo myeloma risk stratification.Results The peripheral blood erythrocyte count,hemoglobin level,lactic acid dehydrogenase(LDH)level and interleukins-8(IL-8)levels of the patients in the EMM group were higher than those in the non-EMM group(P＜0.05),the interleukins-10(IL-10)and the pro-portion of CD4+T cells in the EMM group were lower than those in the non-EMM group(P＜0.05).Lymphocyte counts were signifi-cantly higher(P＜0.05)and the proportion of CD8+T cells was significantly lower(P＜0.05)in the EMM group of patients with stand-ard-risk MM.The proportion of peripheral blood CD8+T cells was significantly lower in the EMM group compared with the non-EMM group of patients with high-risk MM(P＜0.05).LDH levels were higher in the EMM group than that in the non-EMM group in both DS-Ⅰ and DS-Ⅱ MM patients(P＜0.05).Peripheral blood erythrocyte count,monocyte count,and hemoglobin level were higher in the EMM group than those in the non-EMM group in DS-Ⅲ MM patients(P＜0.05).Conclusion Immune abnormalities may be one of the factors contributing to the occurrence,development and poor prognosis of EMM.This study suggest that CD8+T cells,as immune effector cells,can be further studied in the occurrence and progression of MM to EMM,providing a new basis for clinical treatment.
