Epidemiological status of acute hemorrhagic conjunctivitis and influencing factors related outbreak in Fujian Province
10.3969/j.issn.1002-2694.2025.00.079
- VernacularTitle:福建省急性出血性结膜炎流行特征及其暴发的影响因素分析
- Author:
Wenxiang HE
1
;
Linfeng LI
;
Ying ZHU
;
Yuwei WENG
;
Wei CHEN
Author Information
1. 福建省疾病预防控制中心,福建省人兽共患病研究重点实验室,福州 350012
- Publication Type:Journal Article
- Keywords:
acute hemorrhagic conjunctivitis;
CVA24v;
epidemiology;
genetic characteristics
- From:
Chinese Journal of Zoonoses
2025;41(7):742-748
- CountryChina
- Language:Chinese
-
Abstract:
This study was aimed at comprehensively understanding the epidemic status of acute hemorrhagic conjunctivitis(AHC)and influencing factors related outbreak in Fujian Province,to provide valuable insights for AHC prevention and control in this region.We conducted a descriptive statistical analysis of epidemiological data for AHC cases.Additionally,clinical samples collected from a 2023 outbreak were subjected to pathogen detection,determination of full-length nucleotide sequences within the VP1 region,genotype identification,and comprehensive analysis.The peak incidence of AHC in 2023 was observed in September and accounted for a substantial proportion(86.39%,5 205/6 025)of the total cases throughout the year.The three areas with the highest incidence rates were Sanming(118.57/100 000),Longyan(53.83/100 000)and Zhangzhou(16.02/100 000).From 2011 to 2022,the inci-dence of AHC in Longyan City was the highest for consecutive 12 years.During the peak AHC outbreak period in Fujian Province in 2023,all 62 conjunctival swabs collected were identified as CVA24v,and 60 complete VP1 sequences were obtained through se-quencing.The nucleotide sequence identity among these 60 sequences ranged from 98.7%to 100%,whereas the amino acid identity ranged from 98.4%to 100%.The highest nucleotide sequence identity was observed for the 2023 strain isolated from Zhongshan,Guangdong Province(rang:99.0%～100%).The 2023 strains in Fujian Province belonged to the GIV genotype,and L16I represented a potential unique amino acid variation within the sequence.CVA24v was the causative agent responsible for this AHC epidemic,and its GIV genotype is currently the dominant type in China.Future efforts should prioritize AHC prevention and control measures cen-tered in key cities.Monitoring and early warning of AHC in the whole province should be strengthened before September each year,and the variation of pathogen nucleic should also be tracked in time.
