Virulence factors of spotted fever group Rickettsia:a review
10.3969/j.issn.1002-2694.2025.00.086
- VernacularTitle:斑点热群立克次体毒力因子研究进展
- Author:
Wenli DOU
1
;
Kehan XU
1
;
Yan LIU
1
;
Maozhang HE
1
Author Information
1. 安徽医科大学基础医学院,合肥 230032
- Publication Type:Journal Article
- Keywords:
spotted fever group rickettsia;
virulence factors;
pathogenic mechanism;
immune evasion
- From:
Chinese Journal of Zoonoses
2025;41(7):755-761
- CountryChina
- Language:Chinese
-
Abstract:
Spotted fever group Rickettsia(SFGR)are gram-negative,obligate intracellular pathogens that cause spotted fever rickettsiosis,a zoonotic disease.SFGR invade host cells through the expression of outer membrane proteins and Anaplasma-derived proteins.Then they use virulence factors,including phospholipases and cell surface antigens,to evade or suppress host immune de-fenses,thereby facilitating host colonization and intercellular dissemination,and exerting pathogenic effects.This review summarizes current research progress in various SFGR virulence factors,to further elucidate the pathogenic mechanisms of spotted fever rickettsio-sis,and provide a reference for the prevention and treatment of this disease.
