New Progress in the Prevention and Treatment of Depression by Regulating Intestinal Flora with Traditional Chinese Medicine
10.11842/wst.20230819005
- VernacularTitle:中药调控肠道菌群防治抑郁症的新进展
- Author:
Siqi LIU
1
;
Yiliang HU
;
Baitao WANG
;
Huayu WANG
;
Li BAI
;
Mingsan MIAO
Author Information
1. 河南中医药大学药学院 郑州 450000
- Publication Type:Journal Article
- Keywords:
Depression;
Intestinal flora;
Chinese medicine;
Action mechanism
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2024;26(10):2522-2527
- CountryChina
- Language:Chinese
-
Abstract:
The incidence of depression is increasing year by year,seriously affecting people's work and life.With the continuous in-depth study of its pathogenesis,it is found that depression is closely related to intestinal flora.The imbalance of intestinal flora can cause central nervous system diseases through the microbial-brain-gut axis,which involves neurotransmitters,neuroendocrine,neurotrophic factors,inflammatory response and other mechanisms.This paper introduced intestinal flora and relevant regulatory factors related to various mechanisms of depression,listed experimental examples of intestinal flora imbalance leading to depression,and then summarized relevant studies on the anti-depression mechanism of traditional Chinese medicine through regulation of intestinal flora according to the mechanism of action,among which the regulation of microbial metabolism,inflammatory factors and neurotransmitters was mainly studied.The conclusion is expected to provide some reference for the study of anti-depression effect of Chinese medicine.
