Mechanisms and research progress of tanshinone ⅡA in the prevention and treatment of radiation-induced heart disease
- VernacularTitle:丹参酮ⅡA在放射性心脏损伤防治中的作用机制及研究进展
- Author:
Yan-ling LI
1
;
Zhi-ling GAO
;
Gang WANG
;
Ping XIE
Author Information
- Publication Type:Journal Article
- Keywords: Radiation-induced heart disease; Tanshinone ⅡA; Mechanism of action; Oxidative stress; Fibrosis; Target; Thera-py
- From: Chinese Pharmacological Bulletin 2025;41(12):2236-2240
- CountryChina
- Language:Chinese
- Abstract: Radiation-induced heart disease(RIHD)is a common and severe complication following radiotherapy for thoracic tumors,significantly impacting patients' long-term prognosis and quality of life.Its pathogenesis is complex,primarily involving oxidative stress,inflammatory responses,endothelial dysfunction,and chronic fibrosis.Currently,there is a lack of effective clini-cal prevention and treatment methods,highlighting the urgent need to develop intervention strategies for RIHD.Tanshinone ⅡA,the main active component of Salvia miltiorrhiza,exhibits mul-tiple pharmacological effects,including antioxidant,anti-inflam-matory,anti-fibrotic,and anti-apoptotic properties.Studies have shown that Tanshinone ⅡA can significantly mitigate radiation-induced myocardial injury and fibrosis,as well as improve cardi-ac function,by scavenging reactive oxygen species,inhibiting in-flammatory pathways,and modulating fibrotic signaling path-ways.This article summarizes the pathogenesis of RIHD and the research progress on Tanshinone ⅡA in the prevention and treat-ment of RIHD,providing new theoretical insights for developing effective cardioprotective strategies.
