Incidence and influencing factors of frailty in elderly patients with hematologic malignancies: a meta-analysis
10.3760/cma.j.cn115682-20250310-01166
- VernacularTitle:老年血液肿瘤患者衰弱发生率及影响因素的Meta分析
- Author:
Jinying ZHAO
1
;
Zhongfan KAN
;
Longting MA
;
Qianqian ZHANG
;
Yating LIU
;
Rui MA
;
Chunyan PING
;
Yiying ZHANG
;
Yayun CAO
;
Qian YANG
;
Qingyan GAO
;
Xin WANG
;
Wenjun XIE
Author Information
1. 中国医学科学院血液病医院（中国医学科学院血液学研究所）MDS和MPN诊疗中心，血液与健康全国重点实验室，国家血液系统疾病临床医学研究中心，细胞生态海河实验室，天津 300020
- Publication Type:Journal Article
- Keywords:
Aged;
Hematologic neoplasms;
Frailty;
Influencing factors;
Meta-analysis
- From:
Chinese Journal of Modern Nursing
2025;31(30):4144-4151
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To systematically analyze the incidence and influencing factors of frailty in elderly patients with hematologic malignancies.Methods:Research on frailty in elderly patients with hematologic malignancies was retrieved from Chinese and English databases such as China National Knowledge Infrastructure, Wanfang Data, PubMed, and Web of Science. The search period was from database establishment to August 23, 2024. Two researchers screened the included studies, conducted quality assessment, and extracted data. Meta-analysis was conducted using Stata 18 and RevMan 5.4.Results:A total of seven studies were included, encompassing 19 076 elderly hematologic malignancy patients, with a frailty incidence of 59% [95% CI (0.48, 0.69) ]. Meta-analysis revealed that age [ MD=4.31, 95% CI (3.67, 4.96) ], gender [ OR=0.88, 95% CI (0.83, 0.93) ], alcohol consumption [ OR=1.67, 95% CI (1.15, 2.44) ], self-care ability [ MD=-1.79, 95% CI (-3.17, -0.41) ], anemia [ OR=6.67, 95% CI (2.94, 15.14) ], infection [ OR=1.81, 95% CI (1.16, 2.84) ], and neuropathy [ OR=2.52, 95% CI (1.38, 4.61) ] were the influencing factors of frailty in elderly patients with hematologic malignancies. Conclusions:The incidence of frailty is high in elderly patients with hematologic malignancies. Elderly patients with hematologic malignancies who are older, female, consume alcohol, have low self-care ability, anemia, infections, and neuropathy are prone to frailty. Healthcare providers can conduct early screening and intervention for high-risk populations of frailty based on risk factors to improve the quality of life for elderly hematologic malignancy patients.
