cGAS/STING Pathway and its Neuroimmune Mechanism in the Improvement of Rheumatoid Arthritis by Acupuncture
- VernacularTitle:cGAS/STING通路及其在针刺改善类风湿性关节炎的神经免疫机制研究新思路
- Author:
Yuan LI
1
;
Yuan XU
;
Gongming YUAN
;
Shengfeng LU
;
Ning WANG
Author Information
- Publication Type:Journal Article
- Keywords: Acupuncture; Rheumatoid arthritis; cGAS/STING pathway; Neuroimmune mechanism; Research ideas
- From: World Science and Technology-Modernization of Traditional Chinese Medicine 2024;26(10):2539-2544
- CountryChina
- Language:Chinese
- Abstract: Acupuncture is often used in the clinical treatment of Rheumatoid arthritis(RA).However,its mechanism of action remains unclear.DNA sensing activates innate immunity and induces inflammatory responses through the cyclic GMP-AMP synthase(cGAS)/stimulator of interferon genes(STING)pathway.Meanwhile,STING mediated type-Ⅰinterferons(IFNs-Ⅰ)signaling has been proved to be a key regulatory molecule of nociception,which has become a potential target for RAtreatment.This article reviews the molecular mechanisms and functions of cGAS/STING activation and signal transduction,with particular emphasis on the antinociception effect of this signaling pathway in neuro-immune interactions in the peripheral nervous system,and envisage new ideas for the study of the neuroimmune mechanism of acupuncture in improving RA,which provides a new research direction for the treatment of RA and other autoimmune diseases related to immune disorders.It also provides new strategies and methods for the clinical transformation of intervention STING pathway.
