The Role of tryptophan metabolism in modulating microbiota-gut-brain communication in chronic fatigue syndrome
10.3969/j.issn.1006-5725.2025.23.023
- VernacularTitle:色氨酸代谢对慢性疲劳综合征微生物-肠-脑通讯影响的研究进展
- Author:
Ming JIN
1
;
Sitong FANG
;
Lingjun KONG
;
Qingguang ZHU
;
Min FANG
Author Information
1. 上海中医药大学附属曙光医院推拿科(上海 201203)
- Publication Type:Journal Article
- Keywords:
chronic fatigue syndrome;
tryptophan;
5-HT;
kynurenine;
gut-brain axis
- From:
The Journal of Practical Medicine
2025;41(23):3786-3792
- CountryChina
- Language:Chinese
-
Abstract:
The pathogenesis of chronic fatigue syndrome(CFS)remains poorly defined,and while the tryptophan metabolic pathway is closely associated with the development of CFS,the underlying mechanisms are not yet fully understood.This review examines the alterations in tryptophan metabolites and related enzymes in both peripheral and central systems of CFS patients,with a particular focus on the involvement of the tryptophan pathway in the gut-brain axis(GBA).Furthermore,it provides a comprehensive analysis of the mechanistic roles of tryptophan metabolites in modulating the progression of CFS,aiming to elucidate the current evidence and potential driving mechanisms linking the tryptophan metabolic pathway to CFS,thereby promoting new insights and advancements in this research domain.
