Research progress on the mechanism of IKKε/TBK1 pathway in the pathogenesis of type 2 diabetes mellitus based on inflammatory response
10.3969/j.issn.1006-6187.2025.01.014
- VernacularTitle:基于炎症反应探讨核因子κB激酶抑制剂ε/TANK结合激酶1通路在2型糖尿病作用机制的研究进展
- Author:
Yujiao YANG
1
;
Shuquan LYU
Author Information
1. 050091 石家庄,河北中医药大学研究生学院
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,type 2;
IKKε;
TBK1;
Signal pathway;
Action mechanism
- From:
Chinese Journal of Diabetes
2025;33(1):77-80
- CountryChina
- Language:Chinese
-
Abstract:
Nuclear factor κB(NF-κB),the activation of signaling pathways is closely related to the development of chronic inflammation.Multiple pro-inflammatory factors activate NF-κB kinase inhibitor ε/TANK binding kinase 1(IKKε/TBK1),pancreatic islets β cellular dysfunction or loss leads to type 2 diabetes mellitus(T2DM).Inhibiting or blocking IKKε/TBK1 can reduce the production of inflammatory factors,lower insuin resistance,improve insulin sensitivity,and reduce the occurrence of T2DM.This article reviews the action mechanism based on inflammatory response ε/research progress on the mechanism of action IKKε/TBK1 pathway in T2DM.
