Diabetes combined with intrahepatic cholestasis and hepatocellular carcinoma caused by a mutation of ABCB11 gene-a case report
10.3969/j.issn.1006-6187.2025.01.011
- VernacularTitle:糖尿病合并由ABCB11基因突变导致的肝内胆汁淤积症及肝细胞癌一例报道
- Author:
Lijun CHANG
1
;
Conghui CAO
;
Xiaoli WANG
Author Information
1. 118300 丹东,东港市中心医院内分泌科
- Publication Type:Journal Article
- Keywords:
ABCB11 gene;
BSEP protein;
Intrahepatic cholestasis;
Diabetes mellitus;
Hepatocellular carcinoma
- From:
Chinese Journal of Diabetes
2025;33(1):65-69
- CountryChina
- Language:Chinese
-
Abstract:
This paper reports an early-onset diabetes patient combined with intrahepatic cholestasis and hepatocellular carcinoma caused by a mutation of ABCB11 gene.After surgery and drug treatment,the patient's digestive tract symptoms and diabetes were alleviated.Diabetes with primary intrahepatic cholestasis has not been reported in the literature.By introducing this case's clinical manifestations,genetic characteristics and clinical course,we hope to provide a reference for clinicians to understand the diagnosis,treatment and follow-up of this disease.
