Application and research progress in the use of zebrafish in inflammatory bowel disease research
10.3969/j.issn.1005-4847.2025.10.015
- VernacularTitle:斑马鱼模型在炎症性肠病中的应用及研究进展
- Author:
Liyan XU
1
;
Fangzhen LI
1
;
Yuxin WANG
1
;
Meng JIN
1
;
Yun ZHANG
1
;
Kechun LIU
1
;
Rongchun WANG
1
Author Information
1. 齐鲁工业大学(山东省科学院),生物研究所,济南 250103
- Publication Type:Journal Article
- Keywords:
zebrafish;
inflammatory bowel disease;
animal model;
drug screening
- From:
Acta Laboratorium Animalis Scientia Sinica
2025;33(10):1539-1545
- CountryChina
- Language:Chinese
-
Abstract:
Inflammatory bowel disease(IBD)is a non-specific chronic inflammatory bowel condition.Crohn's disease(CD)and ulcerative colitis(UC)are the 2 main types of IBD.IBD is prone to recurrent attacks,which is associated with many factors,such as immune dysfunction,intestinal microenvironment homeostasis imbalance,and environmental and genetic factors;however,its specific pathogenesis is still unclear.Zebrafish has recently emerged as an emerging animal model and have been used extensively for mechanistic research into IBD,model construction,activity evaluation,and screening of anti-IBD agents,due to their unique biological advantages.Based on the latest research progress using zebrafish in the field of IBD,this review systematically introduces the intestinal development characteristics,tissue structure,intestinal immunity,IBD model,and the application of drug screening in zebrafish,to demonstrate the value of zebrafish in the study of IBD.
