Research progress on rat model of chronic thromboembolic pulmonary hypertension
10.3969/j.issn.1005-4847.2025.10.014
- VernacularTitle:慢性血栓栓塞性肺动脉高压大鼠模型研究进展
- Author:
Xuekai LIU
1
;
Xiang ZHONG
;
Juanjuan ZHANG
;
Xiaolong SUN
;
Pan WU
;
Zhenchuan PANG
;
Ping XIE
Author Information
1. 甘肃中医药大学第一临床医学院,兰州 730000;陇西县第一人民医院,甘肃陇西 748100
- Publication Type:Journal Article
- Keywords:
CTEPH;
modeling method;
rat model;
research progress
- From:
Acta Laboratorium Animalis Scientia Sinica
2025;33(10):1531-1538
- CountryChina
- Language:Chinese
-
Abstract:
Chronic thromboembolic pulmonary hypertension(CTEPH)is a severe form of pulmonary hypertension(PH),and is classified as the fourth major category of pulmonary arterial hypertension.CTEPH is primarily caused by chronic thrombosis,leading to the obstruction of blood flow in the pulmonary arteries and result ing in a sustained increase in pulmonary artery pressure.The unclear pathogenesis of CTEPH,however,means that its early diagnosis is challenging,treatment options are limited,and prognosis assessment is often inaccurate.In-depth research into these mechanisms will thus improve our understanding of the pathophysiological processes of CTEPH,and also provide a theoretical basis for developing new therapeutic strategies.This review focuses on the current method of establishing CTEPH rat models and their advantages and disadvantages,offering researchers a reference for selecting and constructing CTEPH rat models.
