Analysis of Animal Models of Attention Deficit Hyperactivity Disorder based on Clinical Characteristics of Traditional Chinese and Western Medicine
- VernacularTitle:基于中西医临床病症特点的注意力缺陷多动障碍啮齿类动物模型分析
- Author:
Heyun JING
1
;
Le KANG
;
Yabo DONG
;
Yanli YANG
;
Yuan WANG
;
Xiumin LI
;
Mingsan MIAO
Author Information
- Publication Type:Journal Article
- Keywords: Attention deficit hyperactivity disorder; Animal model; Characteristics of Chinese and western medicine; Diagnostic criteria
- From: World Science and Technology-Modernization of Traditional Chinese Medicine 2024;26(11):2959-2967
- CountryChina
- Language:Chinese
- Abstract: Attention deficit hyperactivity disorder(ADHD),also known as childhood hyperactivity disorder,is a very common clinical disorder in children,which seriously affects their physical and mental health.Animal models conforming to the clinical diseases of Chinese and Western medicine are the basis for in-depth research on the pathogenesis and prevention and treatment of ADHD.Taking"Attention Deficit Hyperactivity Disorder"as the theme,this paper summarizes the modeling methods and model features of ADHD animal models in CNKI,Wanfang,Wipu,and pubmed databases in the past 20 years,evaluates their strengths and weaknesses,and analyzes the extent to which the models are in agreement with the clinical diseases of Chinese and Western medicine.The results show that there are many existing animal models of ADHD,which can be mainly divided into three kinds:spontaneous model,induced model and gene model,among which the SHR rat model has become a popular and ideal animal model because of its good surface validity,moderate price and other advantages.Currently,animal models of ADHD are dominated by disease models of Western medicine,and models that meet the characteristics of Chinese medicine clinical conditions are rare,with insufficient reflection of Chinese medicine evidence.Therefore,it is suggested that the subsequent construction of animal models of ADHD should consider adding the relevant pathogenic factors and indexes of different certificates of Chinese medicine,such as the animal's tongue,mental state,water intake and heart rate,etc.,with the aim of constructing an animal model that is more close to the clinic.
