Model Study and Comparison of Models for Autoimmune Thyroid Disease and its Complications
- VernacularTitle:自身免疫甲状腺疾病及其并发症模型研究与比较
- Author:
Shuang ZHANG
1
;
Yufeng YANG
;
Ningzi ZANG
;
Yan SHI
;
Pin LI
Author Information
- Publication Type:Journal Article
- Keywords: Autoimmune thyroid disease; Complications of autoimmune thyroid disease; Animal models; Modeling method
- From: World Science and Technology-Modernization of Traditional Chinese Medicine 2024;26(11):2951-2958
- CountryChina
- Language:Chinese
- Abstract: Autoimmune thyroid disease(AITD)is a common organ-specific autoimmune disease.The pathological features are significantly increased titers of Thyroglobulin antibody(TgAb)and/or Thyroid peroxidase antibody(TPOAb),accompanied by lymphocyte infiltration in thyroid tissue.The incidence of this disease is increasing year by year,its pathogenesis is complex,and its complications such as Hashimoto's encephalopathy,infertility or abortion,and related nephropathy are harmful.Therefore,this disease has become one of the research hotspots in this field.Animal models play a crucial role in basic disease research.In recent years,many scholars have revealed the etiology,pathogenesis,complications,and therapeutic intervention mechanisms of traditional Chinese and Western medicine through different animal models of AITD.In this paper,animal selection,specific modeling methods and model evaluation of mouse models of AITD and its complications in recent years were summarized and analyzed,so as to provide a reference for the selection of animal models for AITD basic experimental research.
