Research progress of lactylation modification in colorectal cancer
10.13315/j.cnki.cjcep.2025.10.014
- VernacularTitle:乳酸化修饰在结直肠癌中的研究进展
- Author:
Juan LIU
1
;
Wenjuan GAN
1
Author Information
1. 苏州大学附属第四医院(苏州市独墅湖医院)病理科,苏州 215000
- Publication Type:Journal Article
- Keywords:
colorectal neoplasms;
lactylation;
tumor microenvironment;
molecular mechanism;
literature review
- From:
Chinese Journal of Clinical and Experimental Pathology
2025;41(10):1352-1356
- CountryChina
- Language:Chinese
-
Abstract:
Colorectal cancer(CRC)is a common malignant tumor worldwide,and recurrence and metastasis are the main causes of death.Therefore,it is of great clinical significance to explore the molecular mechanisms that affect the occurrence and development of CRC.Lactylation is a newly recognized post-translational modification of proteins,which can directly stimulate gene transcription of chromatin,enhance protein stability,and promote tumor occurrence and development.Studies have found that lactylation is closely related to the occurrence and development of CRC.This article reviews the research progress of lactylation in CRC,aiming to provide new ideas for the treatment of CRC.
