Clinicopathological analysis of 18 cases of chief cell predominant oxyntic gland ad-enoma of the stomach
10.13315/j.cnki.cjcep.2025.10.007
- VernacularTitle:胃泌酸腺腺瘤主细胞型18例临床病理学分析
- Author:
Liyong GAO
1
;
Dongmei QIN
;
Hongxia JING
;
Guiying TANG
;
Xiaomei ZHANG
;
Dan ZHOU
;
Fulong YU
;
Wei QIU
Author Information
1. 徐州市第一人民医院病理科,徐州 221000
- Publication Type:Journal Article
- Keywords:
gastric oxyntic gland adenoma;
histomorphology;
immunohistochemistry;
treatment;
prognosis
- From:
Chinese Journal of Clinical and Experimental Pathology
2025;41(10):1308-1313
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To investigate the clinicopathological characteristics of the gastric oxyntic gland adenoma(GOGA).Methods We collected 18 samples of GOGA,histopathological features and immunohistochemical staining were assessed.Main features of pathological diagnosis,treatment methods and follow-up were retrospectively analyzed.Results There were 18 patients,including 9 females and 9 males,aged from 36 to 86 years old.The endoscopic im-age showed a flat lesion with whitish in color or a polypoid protrusions.The size ranged from 0.3 cm to 0.8 cm.Hema-toxylin and eosin staining showed irregular glandular structures in the mucosal lamina propria,with branched and anas-tomosed patterns.The tumour demonstrating composed of chief cells hyperplasia with mild nuclear atypia.All lesions were confined to the mucous lamina propria.There was no atrophic within the peripheral gastic mucosa.Immunohisto-chemical examination showed positive for Pepsinogen-Ⅰ and MUC6.Gene mutation were analyzed in 2 cases using next generation sequence technology,and no KRAS and GNAS mutation had been detected.Endoscopic surgical treatment was performed in 11 cases,and biopsy forceps removal was carried out in 7 cases.No recurrence or metastasis was ob-served during the follow-up period of 1 to 58 months.Conclusion GOGA is a rare lesion,and appears to behave bio-logically benign.A full understanding of its histological morphology and biological behavior can improve the diagnostic ability of clinincans,and facilitate further research in the future.
