Research progress on the molecular mechanisms of cancer-associated fibroblasts mediating therapeutic resistance in gastric cancer and targeted strategies
10.13315/j.cnki.cjcep.2025.10.015
- VernacularTitle:肿瘤相关成纤维细胞介导胃癌治疗耐药的分子机制及靶向治疗策略研究进展
- Author:
Shiyang DENG
1
;
Jiang DU
1
Author Information
1. 中国医科大学基础医学院病理学教研室,沈阳 110122
- Publication Type:Journal Article
- Keywords:
gastric neoplasms;
cancer-associated fibroblasts;
therapeutic resistance;
molecular mechanisms;
targeted therapy;
literature review
- From:
Chinese Journal of Clinical and Experimental Pathology
2025;41(10):1357-1364
- CountryChina
- Language:Chinese
-
Abstract:
Cancer-associated fibroblasts(CAFs),as major components of the tumor microenvironment,play a pivotal role in therapeutic resistance in gastric cancer.Evidence shows that CAFs contribute to resistance through vari-ous multiple mechanisms,including exosomal signaling,metabolic reprogramming,extracellular matrix remodeling,and immune modulation.Although the regulatory network of CAFs is highly complex and the clinical translation of relat-ed therapeutic strategies remains challenging,precise targeting CAFs offers a promising avenue for overcoming drug re-sistance and improving patient outcomes.This review summarizes the molecular mechanisms by which CAFs mediate resistance and signaling pathways,biomarker-based immunotherapy,and emerging combination regimens,aiming to provide novel insights for gastric cancer treatment.
