Changes in serum NOV/CCN3 levels in mid-to late-term pregnant women and their association with gesta-tional diabetes mellitus and pregnancy outcome
10.3969/j.issn.1006-5725.2025.01.012
- VernacularTitle:中晚期孕妇血清NOV/CCN3水平变化及其与妊娠期糖尿病、妊娠结局的关系
- Author:
Wenjing ZHENG
1
;
Xiangling CHU
;
Yuqiong WU
;
Min ZHANG
;
Xiaohong CHU
;
Nan ZHANG
;
Honglin HU
Author Information
1. 安徽医科大学第一附属医院内分泌科(安徽 合肥 230000)
- Publication Type:Journal Article
- Keywords:
gestational diabetes mellitus;
NOV/CCN3;
pregnancy outcomes;
insulin resistance;
obesity
- From:
The Journal of Practical Medicine
2025;41(1):71-77
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate alterations in serum NOV/CCN3 levels among women during mid-to-late pregnancy and elucidate its association with gestational diabetes mellitus(GDM)and pregnancy outcomes.Methods Based on the results of an oral glucose tolerance test(OGTT),we categorized 252 pregnant women into two groups:the GDM group and the control group.Within the GDM group,participants were further stratified based on pre-pregnancy body mass index levels and pregnancy outcomes.We collected clinical data for all study subjects and compared differences in general information,biochemical indicators,as well as NOV/CCN3 levels between these groups.Results The serum levels of NOV/CCN3 in the GDM group were significantly higher compared to those in the control group(P<0.001).Spearman correlation analysis revealed a positive association between serum NOV/CCN3 and pre-pregnancy body weight,pre-pregnancy body mass index,insulin resistance index,and total cholesterol;while a negative correlation was observed with insulin sensitivity index(P<0.05).Logistic regression analysis demonstrated that NOV/CCN3 is an independent risk factor for the development of GDM[OR=1.097,95%CI(1.020～1.179),P=0.013],as well as adverse pregnancy outcomes in GDM patients[OR=1.032,95%CI(1.020～1.045),P<0.001].ROC analysis indicated AUCs of 0.840 and 0.784 for these associations respectively(P<0.05).Conclusions Serum levels of NOV/CCN3 in pregnant women at mid-to late-stage are associated with obesity,insulin resistance,and glucose-lipid metabolism,suggesting a potential role of NOV/CCN3 in glycolipid metabolism during gestational diabetes mellitus(GDM).These findings provide novel insights for assessing the occurrence of GDM and predicting pregnancy outcomes in mid-to late-stage pregnancies.
