Expression of TLDC2 in colorectal adenocarcinoma and its clinical significance
10.13315/j.cnki.cjcep.2025.10.003
- VernacularTitle:结直肠腺癌中TLDC2的表达及临床意义
- Author:
Junyi FENG
1
;
Jing MA
;
Danhui ZHAO
;
Yingmei WANG
;
Junhui QIN
;
Juan DU
;
Zhe WANG
;
Shuangping GUO
Author Information
1. 空军军医大学第一附属医院病理科,西安 710032
- Publication Type:Journal Article
- Keywords:
colorectal neoplasms;
adenocarcinoma;
tissue microarray;
TLDC2;
immunohistochemistry
- From:
Chinese Journal of Clinical and Experimental Pathology
2025;41(10):1273-1280
- CountryChina
- Language:Chinese
-
Abstract:
Purpose This study aimed to investigate the expression and clinical significance of TLDC2 in colorec-tal adenocarcinoma.Methods Data from the human protein atlas(HPA)and the cancer genome atlas(TCGA)indi-cated that TLDC2 was highly expressed in colorectal adenocarcinoma.We further analyzed the expression of TLDC2 in 400 colorectal adenocarcinomas and 447 other solid tumors using tissue microarrays and immunohistochemical(IHC)staining.Result The positive expression rate of TLDC2 was significantly higher than that of SATB2 in colorectal ade-nocarcinomas(96.5％vs 87.0％,P＜0.000 1).TLDC2 positivity exceeded that of SATB2 in both low-or high-grade colorectal adenocarcinoma(99.4％vs 88.7％,P＜0.000 1;83.3％vs 79.2％,P=0.669 9).In addition,the expression of TLDC2 and SATB2 was evaluated in 447 cases of other types of solid tumors.TLDC2 was expressed in neuroendocrine tumors as well as in gastric and appendiceal adenocarcinomas,whereas SATB2 was detected in a small number of melanomas,ovarian cancers,breast cancers and gallbladder cancers.The positive and specificity of TLDC2 for colorectal adenocarcinoma were 97％(95％CI=0.94-0.98)and 85％(95％CI=0.81-0.88),respectively.Combined detection of TLDC2 and SATB2 yielded a sensitivity of 96％(95％CI=0.93-0.97)and a specificity of 93％(95％CI=0.90-0.95).Conclusion Analysis of large-scale datasets and IHC staining demonstrated that TLDC2 is a highly sensitive and specific biomarker for colorectal adenocarcinoma.
