The Mechanism of Necroptosis in Cancer Therapy
10.13865/j.cnki.cjbmb.2025.07.1169
- VernacularTitle:坏死性凋亡在肿瘤治疗中的作用机制
- Author:
Yan-Ping NING
1
;
Liu-Yan CHEN
;
Su-Fang ZHOU
Author Information
1. 广西医科大学基础医学院免疫学教研室,南宁 530021;广西高校生物分子医学研究重点实验室,南宁 530021;广西钦州市第二人民医院输血科,广西 钦州 535000
- Publication Type:Journal Article
- Keywords:
necroptosis;
malignant tumor;
cell survival;
apoptosis;
pyroptosis
- From:
Chinese Journal of Biochemistry and Molecular Biology
2025;41(11):1622-1632
- CountryChina
- Language:Chinese
-
Abstract:
Cell death is classified into programmed cell death(PCD)and non-programmed cell death(NCD).Necroptosis is a form of PCD that does not rely on caspases and is regulated by four signaling pathways:receptor-interacting protein kinase 1/3(RIPK1-RIPK3),TIR-domain-containing adapter-in-ducing interferon-β(TRIF)-RIPK3,Z-DNA binding protein 1(ZBP1)-RIPK3,and type Ⅰ/Ⅱ interferon receptors(IFNRs).These pathways interact to regulate the activity of core molecules such as RIPK1,RIPK3,and mixed lineage kinase domain-like protein(MLKL),thereby determining the occurrence of necroptosis.The dysregulation of these pathways can lead to the development of various diseases,inclu-ding cancer.Necroptosis not only inhibits tumor occurrence and progression by promoting tumor cell death,but also creates a tumor microenvironment(TME)conducive to tumor cell growth through its pro-inflammatory properties,thereby promoting tumor growth and metastasis.Therefore,the dual role of nec-roptosis in cancer makes it an important research direction in tumor treatment.This article reviews the key signaling pathways of necroptosis,explores its interactions with other cell death pathways such as cell survival,apoptosis,and pyroptosis.Meanwhile,it analyzes the dual regulatory mechanisms of necropto-sis in cancer progression and discusses the issue of overcoming tumor treatment resistance by modulating necroptosis.It further explores its potential therapeutic targets and application prospects,aiming to pro-vide new intervention strategies and theoretical basis for cancer treatment.
