Advances in clinicopathological characteristics of fumarate hydratase deficient pul-monary benign metastasizing leiomyoma
10.13315/j.cnki.cjcep.2025.11.014
- VernacularTitle:延胡索酸水合酶缺陷型肺良性转移性平滑肌瘤临床病理学特征及进展
- Author:
Haiqing SI
1
;
Pingli SUN
1
Author Information
1. 吉林大学第二医院病理科,长春 130000
- Publication Type:Journal Article
- Keywords:
lung neoplasms;
leiomyoma;
metastasis;
fumarase hydratase deficiency;
literature review
- From:
Chinese Journal of Clinical and Experimental Pathology
2025;41(11):1499-1503,1508
- CountryChina
- Language:Chinese
-
Abstract:
Benign metastasizing leiomyomatosis is a rare clinical entity characterized by benign leiomyomas occur-ring outside the uterus,with the lungs being the most commonly involved site,thus termed pulmonary benign metastasi-zing leiomyomatosis.Fumarate hydratase(FH)-deficient leiomyoma represents a rare pathological variant of uterine leiomyoma,which is of great significance for screening hereditary leiomyomatosis and renal cell carcinoma syndrome.Although there have been reports of FH-deficient leiomyomas involving the lungs,studies on FH-deficient pulmonary benign metastasizing leiomyoma in this context remain limited.This article offers a comprehensive review of existing studies on FH-deficient pulmonary benign metastasizing leiomyoma by integrating the epidemiology,clinical manifesta-tions,pathological features,diagnosis,differential diagnosis,and therapeutic advancements of primary uterine FH-de-ficient leiomyoma.
