Ovarian mature cystic teratoma with mucinous tumors:a clinicopathological anal-ysis of 14 cases
10.13315/j.cnki.cjcep.2025.11.010
- VernacularTitle:卵巢成熟性囊性畸胎瘤伴黏液性肿瘤14例临床病理分析
- Author:
Xiaoxiao ZHAO
1
;
Shuaijun CHEN
1
;
Bo LUO
1
;
Yonghui XIE
1
;
Hongfeng ZHANG
1
Author Information
1. 华中科技大学同济医学院附属武汉中心医院病理科,武汉 430014
- Publication Type:Journal Article
- Keywords:
teratoma;
mucinous neoplasms;
histological morphology;
immunophenotype;
differential diagnosis;
treat-ment;
prognosis
- From:
Chinese Journal of Clinical and Experimental Pathology
2025;41(11):1472-1477,1484
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To investigate the clinicopathological features,diagnosis,differential diagnosis,immuno-phenotype,and prognosis of ovarian mature cystic teratoma(MCT)with an associated mucinous tumor(MT).Meth-ods Clinicopathological and follow-up data from 14 cases of MCT with MT were retrospectively analyzed and supple-mented with a literature review.Results 14 patients' ages ranged from 21-70 years,with a median age of 33 years.Tumors were located in the left ovary(4 cases),right ovary(9 cases),or bilaterally(1 case).The tumors,cystic or cyst-solid,measured 6.0-24.0 cm in maximum diameter(mean:11.7±5.7 cm).Histologically,the MT compo-nents were classified as mucinous cystadenoma(MCA)in 9 cases,borderline mucinous cystadenoma(MBT)in 4 ca-ses,and mucinous adenocarcinoma(MAC)in 1 case.Microscopically,MCT elements from multiple germ layers were identified in 13 cases,with one case showing only mature thyroid tissue.The mucinous epithelium in MCA showed no significant atypia.Mucinous epithelial proliferation accounted＞10％in MBT.MAC demonstrated moderate-to-severe atypia and invasive growth.Immunohistochemically,the MT epithelium was frequently positive for CK7(6/7),CK20(4/5),CDX2(5/6),Villin(4/4),SATB2(3/3),MUC2(2/3),MUC5AC(2/2),MUC6(1/1),and PAX-8(2/7),while negative for ER(6/6),PR(5/5),and WT-1(5/5).The Ki-67 proliferation index was low(＜5％)in 6 cases and high(50％)in one case.During a follow-up of 9-110 months,patients with MCT associated with MCA or MBT were alive without recurrence.The patient with MCT and MAC experienced recurrence 34 months after surgery.Conclusion Ovarian MCT with MT is rare and lacks specific clinical manifestations.Pathological examina-tion combined with immunophenotyping is essential for accurate diagnosis and classification.
