Correlation of DCE-MRI parameters and serum PCSK9 level with pathological characteristics and chemotherapy sensitivity of breast cancer patients
10.16753/j.cnki.1008-2344.2025.06.010
- VernacularTitle:DCE-MRI参数、血清PCSK9水平与乳腺癌患者病理特征及化疗敏感性的相关性
- Author:
Weiqi ZHANG
1
;
Ting ZHANG
1
;
Shuai LI
1
Author Information
1. 三门峡市中心医院磁共振诊断中心,河南 三门峡 472000
- Publication Type:Journal Article
- Keywords:
breast cancer;
dynamic contrast-enhanced magnetic resonance imaging parameters;
proprotein convertase subtilisin/kexin type 9;
pathological characteristics;
chemotherapy sensitivity;
correlation
- From:
Journal of Shenyang Medical College
2025;27(6):619-625
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the correlation of dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI)parameters and serum level of proprotein convertase subtilisin/kexin type 9(PCSK9)with pathological characteristics and chemotherapy sensitivity of breast cancer patients.Methods:The clinical data of 102 breast cancer patients admitted to our hospital from Feb 2022 to May 2024 were respectively analyzed.Based on the principle of 1∶1 selection,102 patients with benign breast tumors during the same period were selected as the control group.The DCE-MRI parameters[transport constant(Ktrans),rate constant(Kep),volume ratio of the external space(Ve),and apparent diffusion coefficient(ADC)]and serum PCSK9 level were compared between the two groups and patients with different pathological characteristics,and the correlation was analyzed.The value of DCE-MRI parameters(Ktrans,Kep,Ve,ADC)combined with serum PCSK9 level in assessing the sensitivity of chemotherapy in breast cancer patients was analyzed.Results:The Ktrans,Kep,Ve,ADC values,and serum PCSK9 level in breast cancer group were higher than those in the benign breast tumor group(P＜0.01).Breast cancer patients with low-to-moderate differentiation,pathological stage Ⅲ,and lymph node metastasis had higher Ktrans,Kep,Ve,ADC values,and serum PCSK9 level compared to those with high differentiation,pathological stage Ⅰ-Ⅱ,and no lymph node metastasis(P＜0.05).The degree of differentiation,pathological stage,and lymph node metastasis were positively correlated with Ktrans,Kep,Ve,ADC values,and serum PCSK9 level(P＜0.01).The Ktrans,Kep,Ve,ADC values,and serum PCSK9 level in breast cancer patients with chemotherapy resistance were higher than those in patients with chemotherapy sensitivity(P＜0.01).Patients with chemotherapy resistance had a higher proportion of low-to-moderate differentiation,pathological stage Ⅲ,and lymph node metastasis than patients with chemotherapy sensitivity(P＜0.05).After adjusting the degree of differentiation,pathological stage and lymph node metastasis,Ktrans,Kep,Ve,ADC values and serum PCSK9 level were still the influencing factors of chemotherapy sensitivity in breast cancer patients(P＜0.05).Conclusion:DCE-MRI parameters and serum PCSK9 level are correlated with the clinical pathological characteristics of breast cancer patients,and the combination of these indicators can provide certain reference value for clinical evaluation of chemotherapy sensitivity in breast cancer patients.
