The Relationship Between Atherogenic Index of Plasma and Rapid Progression of Coronary Non-target Lesions
10.3969/j.issn.1000-3614.2025.11.004
- VernacularTitle:血浆动脉粥样硬化指数与冠状动脉非靶病变快速进展的关系
- Author:
Wei WANG
1
;
Haobo XU
1
;
Juan WANG
1
;
Jiansong YUAN
1
;
Weixian YANG
1
;
Rong LIU
1
;
Shubin QIAO
1
;
Jingang CUI
1
Author Information
1. 中国医学科学院 北京协和医学院 国家心血管病中心 阜外医院 心内科,北京 100037
- Publication Type:Journal Article
- Keywords:
coronary artery disease;
non-target lesion;
rapid progression;
atherogenic index of plasma
- From:
Chinese Circulation Journal
2025;40(11):1076-1080
- CountryChina
- Language:Chinese
-
Abstract:
Objectives:The study assessed the relationship between atherogenic index of plasma(AIP)and the rapid progression of coronary non-target lesions.Methods:A total of 1 247 patients with coronary artery disease who underwent two coronary angiography examinations at Fuwai Hospital,Chinese Academy of Medical Sciences between January 2010 and September 2014 were enrolled in this retrospective study.The AIP is defined as the base 10 logarithm of the ratio of the concentrations of triglyceride to high-density lipoprotein cholesterol.Patients were divided into the high AIP group(n=623)and the low AIP group(n=624)based on the median value of AIP.Lesion rapid progression is defined as an increase of more than 10%in the lumen stenosis of the lesion with a stenosis rate of more than 50%,or an increase of more than 30%in the lumen stenosis rate of the lesion with a stenosis rate of less than 50%,or a progression to total occlusion within 2 years.Results:Median AIP was 0.39(0.23-0.56)in this patient cohort.Rapid progression of non-target lesions occurred in 65(5.21%),including 42(6.74%)in the high AIP group.The Kaplan-Meier curve showed that the cumulative incidence of rapid progression of non-target lesions was higher in the high AIP group than in the low AIP group(HR=1.751,95%CI:1.053-2.912,log-rank P=0.028).In univariate cox analysis,the AIP and high AIP correlated with rapid progression of non-target lesions.After multivariate adjustment,AIP was an independent risk factor for rapid progression of non-target lesions(adjusted HR=2.731,95%CI:1.090-6.844,P=0.032).Conclusions:AIP is an independent risk factor for rapid progression of non-target lesions.AIP should be considered as a biomarker for estimating the risk of cardiovascular disease,along with other traditional risk factors.
