Primary hepatic mucoepidermoid carcinoma:clinicopathologic analysis of 4 cases and literature review
10.13315/j.cnki.cjcep.2024.12.012
- VernacularTitle:原发性肝脏黏液表皮样癌4例临床病理分析并文献复习
- Author:
Qian GU
1
;
Xiaoming WANG
;
Linming LU
;
Xi HUANG
;
Jiajia LI
;
Xiangming WANG
;
Nana GUO
Author Information
1. 皖南医学院病理解剖学教研室,芜湖 241002
- Publication Type:Journal Article
- Keywords:
liver tumor;
mucoepidermoid carcinoma;
clinico-pathologic features;
molecular pathology
- From:
Chinese Journal of Clinical and Experimental Pathology
2024;40(12):1305-1311
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To investigate the clinicopathological features of primary mucoepidermoid carcinoma of the liver(PMCL).Methods The history,clinical data,pathological diagnosis,differential diagnosis,treatment and prognosis of 4 patients with PMCL were retrospectively analyzed.Results All four tumors were located in the left half of the liver and were sol-itary.Microscopic examination showed that tumor cells were composed of three types of cells:epidermal like cells,interme-diate cells,and mucinous cells,with varying proportions.Im-munophenotype:tumor cells showed diffuse strong positivity for CA199 and CK19,while mucous cells showed focal positivity for CEA.CK7 mainly expressed in epidermal like cells and mucous cells,while CK5/6,p40,and p63 expressed in epidermal like cells and intermediate cells.Special staining with AB,PAS,and mucin carmine confirmed the presence of mucous cells,Ki67 proliferation index ranged from 30％to 40％.FISH testing:no MAML2 gene breakage or rearrangement was detected in 4 cases of PMCL,and MAML2 gene amplification occurred in 1 case of tumor.Conclusion The incidence of PMCL is low and present with non-specific clinical manifestations,which often leads to misdiagnosis.The diagnosis should be differentiated from bile duct adenocarcinoma and adenosquamous carcinoma.Moreover,there is currently no established standard treatment for PMCL and has a poor prognosis.
