Research progress on the relationship between frailty and depressive disorders and exercise interventions in older adults
10.3969/j.issn.1002-0152.2025.10.008
- VernacularTitle:老年人衰弱与抑郁障碍的相关性及运动干预研究进展
- Author:
Mingqi WANG
1
;
Lei SU
;
Yifei XIA
;
Shensen LU
;
Lu HAO
;
Yongli ZHANG
;
Zhenchun SHI
Author Information
1. 山东大学体育学院(济南 250061)
- Publication Type:Journal Article
- Keywords:
Elderly;
Frailty;
Depressive disorder;
Relationship;
Comorbidity;
Exercise intervention;
Research progress
- From:
Chinese Journal of Nervous and Mental Diseases
2025;51(10):627-631
- CountryChina
- Language:Chinese
-
Abstract:
Frailty and depressive disorders exhibit a high prevalence and comorbidity rate in the elderly population.Their coexistence significantly reduces patients'quality of life,increases the risk of disability and mortality,and substantially exacerbates the socioeconomic burden.Emerging evidence indicates a significant bidirectional causal relationship between frailty and depressive disorders.The underlying comorbid mechanisms may be related to elevated levels of pro-inflammatory cytokines such as C-reactive protein,neutrophils,and white blood cells.Grey matter volume reduces in specific brain regions including the bilateral thalamus and right precentral gyrus.And abnormal hormone secretion,such as cortisol,resulting from the overactivation of the hypothalamic-pituitary-adrenal axis.Exercise interventions demonstrate positive effects in preventing and managing both frailty and depressive disorders,indicating broad application prospects.However,the underlying mechanisms require further validation.In summary,the comorbidity of frailty and depressive disorders in the elderly requires greater attention.Current evidence supports exercise intervention as an effective therapeutic strategy for improving health outcomes in this population.
