Correlation of plasma T cell subsets and serum IL-6 levels with CT imaging characteristics and their prognostic value in children with mycoplasma pneumoniae pneumonia
10.3969/j.issn.1002-1671.2025.11.022
- VernacularTitle:肺炎支原体肺炎患儿血浆T细胞亚群和血清IL-6水平与CT影像特点的相关性及其对预后的预测价值
- Author:
Fuying WANG
1
;
Zhaojin ZENG
1
;
Junfeng PAN
1
Author Information
1. 上饶市妇幼保健院儿科,江西 上饶 334000
- Publication Type:Journal Article
- Keywords:
mycoplasma pneumoniae pneumonia;
T cell subsets;
interleukin-6;
computed tomography
- From:
Journal of Practical Radiology
2025;41(11):1861-1865
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation between plasma T cell subsets,serum interleukin-6(IL-6)levels and CT imaging characteristics in children with mycoplasma pneumoniae pneumonia(MPP),as well as its predictive value for clinical prognosis.Methods A total of 98 children with MPP were selected as the research subjects and divided into the good prognosis group(n=62)and the poor prognosis group(n=36)according to the clinical prognosis.The correlations between plasma T cell subsets,IL-6 levels,CT imaging characteristics and prognosis were analyzed.The predictive efficacy of plasma T cell subsets and IL-6 levels for poor progno-sis was analyzed.Results The levels of C-reactive protein(CRP),tumor necrosis factor-α(TNF-α),IL-6,CD8+and CD19+in the poor prognosis group were significantly higher than those in the good prognosis group,while the levels of CD3+,CD4+,CD4+/CD8+and CD16+/CD56+were significantly lower than those in the good prognosis group(P＜0.05).The statistical conditions of CT ima-ging characteristics such as pulmonary consolidation,ground-glass change,involvement of lung lobes ≥ 2,patchy consolidation shad-ows,grid nodular shadows,bronchial wall thickening,hilar lymph node enlargement,pleural effusion,and atelectasis in the poor prognosis group were significantly higher than those in the good prognosis group(P＜0.05).CD3+,CD4+,CD8+,CD4+/CD8+,CD19+,CD16+/CD56+and IL-6 had independent correlations with the above CT imaging characteristics.IL-6,CD8+and CD19+were positively correlated with the risk of poor prognosis,while CD3+,CD4+,CD4+/CD8+and CD16+/CD56+were negatively correlated with the risk of poor prognosis(P＜0.05).Individual detection of CD3+,CD4+,CD8+,CD4+/CD8+,CD19+,CD16+/CD56+,IL-6 and the combined detection of the seven indicators had certain predictive value for the occurrence of poor prognosis in patients[area under the curve(AUC)＞0.7].Conclusion Plasma T cell subsets and serum IL-6 levels are important factors influencing the prognosis of children with MPP and are independently related to the CT imaging characteristics.
