Diagnostic efficacy of CT-guided percutaneous lung biopsy combined with rapid on-site evaluation technique and serological testing for pulmonary infection
10.3969/j.issn.1002-1671.2025.11.025
- VernacularTitle:CT引导下经皮肺穿刺活检联合快速现场评价技术及血清学检测对肺部感染的诊断效能
- Author:
Bin LI
1
;
Lina FAN
;
Gang XU
;
Wei GUO
Author Information
1. 武穴市中医医院重症医学科,湖北 武穴 435400
- Publication Type:Journal Article
- Keywords:
pulmonary infection;
percutaneous lung biopsy;
com-puted tomography;
rapid on-site evaluation;
serological testing;
diagnosis
- From:
Journal of Practical Radiology
2025;41(11):1873-1876
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the diagnostic efficacy of CT-guided percutaneous lung biopsy(PTLB)combined with rapid on-site evaluation(ROSE)technique and serological testing for pulmonary infection.Methods A total of 92 patients with suspected pulmonary infection who underwent CT-guided PTLB combined with ROSE were selected.Among them,86 cases of pulmonary infectious lesions were diagnosed by tissue culture examination(observation group).Another 86 healthy volunteers who underwent physical examina-tion during the same period were selected(control group).The sensitivity,specificity,accuracy,and Kappa consistency of CT-guided PTLB combined with ROSE for diagnosing pulmonary infection were analyzed based on tissue culture results,and their receiver oper-ating characteristic(ROC)curves were plotted.Serum levels of procalcitonin(PCT),soluble triggering receptor expressed on myeloid cell-1(sTREM-1),soluble cluster of differentiation 14(sCD14),nuclear factor-κB(NF-κB),Toll like receptor-2(TLR-2),and tumor necrosis factor-α(TNF-α)were collected from both groups,and their diagnostic efficacy were evaluated using ROC curves.Results The sensitivity,specificity,and accuracy of CT-guided PTLB combined with ROSE for diagnosing pulmonary infection were 0.930,0.667,and 0.913,respectively,with a Kappa value of 0.456.The ROC curve analysis showed that the AUC for diagnosing pulmonary infection was 0.798,with a 95％confidence interval of 0.569-1.000.In addition,the levels of PCT,sTREM-1,sCD14,NF-κB,TLR-2,and TNF-α in the observation group were significantly higher than those in the control group(P＜0.05),and the ROC curve analysis revealed these serum indicators were statistically significant for diagnosing pulmonary infection(P＜0.05),with the AUC of 0.993,0.993,0.997,0.987,0.983,and 0.999,respectively.Conclusion CT-guided PTLB combined with ROSE tech-nique has high accuracy,good consistency,and excellent diagnostic efficacy for diagnosing pulmonary infection.Serum PCT,sTREM-1,sCD14,NF-κB,TLR-2,and TNF-α have high diagnostic value for pulmonary infection and can serve as clinical diagnostic indicators.
